[giovannibajo1]

No they won’t, if not in very basic cases that can’t be generalized as a rule of thumb solution. Your suggestion bargains correctness with performance.

If you know you are reading aligned memory and you need to do it with a single word memory access, then you need to use intNN_t* and use htonl or similar functions to byteswap. There’s no way around it.

[kazinator]

The compiler can generate a test for alignment, and then a branch between two pieces of code. However, if the test and branch branch causes pipeline stalls due to bad prediction, it could be worse than just running the byte-banging code unconditionally.