[ehnto]

My least popular comments are also comments I have made with hard won experience in my field.

My not-very-humble guess is that it is two fold: One, if you only have a shallow understanding of something, it is easy to dismiss things as wrong if they don't align with your understanding so far. Two, if you do have a deep understanding of a topic but different experiences in the field, you may have really strong opinions in a different direction.

Disappointingly they are also usually the least discussed comments of mine and I rarely figure out why they were downvoted.

[croissants]

Can you link to some of your "hard won experience" comments? Now I'm curious about them.

[randcraw]

In my case, I work for a large pharmaceutical. Many of the driving forces behind drug development or healthcare decisions arise in business priorities, practices, and regulations that are complex and unintuitive to outsiders. Unless I reinforce my POV with explanation of why and how these subterranean forces drive outcomes, I'm likely to find myself downvoted — presumably because readers discount my perspective as insufficiently plausible or wrong outright, perhaps because I haven't offered enough explanation. But since longwinded explication of arcane background minutiae is tiresome to write and for others to read, so I often demur to the detriment of my score.