Lately I've had great experiences with running any windows programs on linux in wine. It seems to have really matured a lot. There are some issues with my tiling wm but other than that zero problems.
Fortunately I've been able to find native alternatives for almost everything. If it wasn't for games and Winamp I'd probably not bother installing wine. (Winamp is the only player I've found that I can get midi files to play to my Roland UM-ONE).