[mct]

One native-Twitter solution available to you today is to create a private list containing only the people you'd like to read on a regular basis.

https://support.twitter.com/entries/76460-how-to-use-twitter...

[josephb]

This is how I use twitter!

Lists are very useful if you follow are large number of people. Create a few smaller lists of the things you really want to see or that are important.

I created a list for the services I use, I check it once a day to see who's tweeted about something new and improved.

I have another list for co-workers and friends and check that one as my default.