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by snowmaker
2011 days ago
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It's not an unreasonable suggestion (and a lot of people are making it now), but the risk with a single dose is low persistence. We know that the first dose has high effectiveness in the first month, but it may trail off sharply. Or it might not. Since we haven't tried a single dose, we don't know. In animal studies, the second dose was required for a durable response, that's why Pfizer decided to go with it in their trial. |
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