Hacker News new | ask | show | jobs
by tum92 2015 days ago
For 1), the average person here might be better equipped to answer than the average biochemist! Sequences are put back together with de bruijn graphs. Small sequences are compiled into continuous segments based on their overlap. The key piece you might be missing is that there are many many copies of the same genome, randomly fragmented so with luck (or careful experimental design) you’ll have sufficient coverage to complete chromosomes. There’s still lots of tricky regions though.
1 comments

Biochemist here, this is correct. This falls under "bioinformatics" or "computational biology". Most biochemists are more focused on the "wet lab" part of the job, and less on the in silico fun stuff.