It'd take some doing. You wouldn't be able to burn a CD-R backwards without some extra steps; a "blank" CD-R contains some data in the pregroove to identify it as a recordable disc and specify some parameters to the burner. A reverse-rotating drive wouldn't be able to read that data, since it'd be backwards. :)
Presumably if you'd also flip the phases on the head stepper and move any relevant endstops around you might be able to convince the drive to read disks inside-out.
Fairly sure it'd immediately give up due to pregroove shenanigans but it's an amusing idea.