[pldr1234]

There's some value to their fear. I share some of it too.

These are some of the fastest-to-market vaccines ever produced. Some were also developed with technology never used before at this scale.

There's some nuance to the fear though - for example, once frontline, health workers and people like Dr Fauci are vaccinated, and it becomes clear that these are at least as safe as flu vaccines, I'll also likely take one, if only for the sole reason that I sorely miss travel.

[djsumdog]

> it becomes clear

It's won't though, not for at least 1~5 years. All the long term studies are being skipped. So long as this vaccine is a choice, I'm okay with it. But if it becomes required for certain jobs, or to be able to enter a store or venue ... I dunno. The speed that this has been rushed through just does not feel right.

I would rather wait 5 years. I prefer that risk for myself over the risk of a rushed to market vaccine. The trouble is, everyone will yell that you not getting the shot can hurt everyone else.

This gets into the dangerous game of personal agency, liberty and autonomy vs what the State is telling you is mandatory for the safety of all. There won't be enough doses for this to matter for a while, but when it does, we'll see some big ethical concerns and court cases.

[lbeltrame]

> All the long term studies are being skipped.

There are no long term studies. The reason vaccines take so much in "regular" circumstances are:

- Actually finding money to run the trials

- Run Phase 1, 2, 3 trials one after another

- (longest) Waiting for the events (infections) to accrue: if it's not in a pandemic, and with relatively low incidence, this takes years to happen

- Regulatory approval (if not in emergency, that's two years)

- Production scale-up (at least one year)

The fact that vaccines takes years to develop for safety is a myth. It is mostly a matter of time, and the fact that we were used to them taking years. Let's not forget smallpox and rabies vaccinations took far less to be invented, and people devising them didn't even know what viruses were. And also because most of the easy targets are now done. What's left are the harder ones (HIV). SARS-CoV-2 might have been hard, or one of the easy pickings. Luckily, it fell into the "easy" camp.

In this specific case, production was started during the trials, events, due to the fact that the virus is spreading like wildfire in the USA, took a matter of weeks to accrue (from 35 in October to 94 two weeks later, according to the Pfizer data), and the fact that an obscene amount of money was spent meant that most trials were started as soon as possible.

But, even looking at the protocols, you might notice that it ticks all the good boxes for proper clinical research.