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by nkohari 2018 days ago
They don't have adjuvants, but they do have lipid nanoparticles which allow the mRNA to breach cells. It's feasible that they could cause unexpected side effects.

NB: I'm personally going to get the first SARS-CoV-2 vaccine I can get, and I'm incredibly excited about mRNA vaccines in general. But, it's true that any time you inject a chemical into your bloodstream you're taking a calculated risk.
2 comments
lbeltrame 2017 days ago
FTR, FDA has approved a product (not a mRNA vaccine) using lipid nanoparticles in 2018.

mRNA vaccines had also (limited) human testing before these trials in the past years (mostly Phase 1).

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nkohari 2017 days ago
I know. I don't see how it refutes what I said. I'm not anti-vaccine, I was just replying to the parent comment suggesting that because these mRNA vaccines don't use adjuvants they wouldn't have side effects.

All medicines represent calculated risks -- risks that are often worth taking, but still risks.

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hhas01 2018 days ago
Please name a vaccine that is injected into your bloodstream.
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nkohari 2018 days ago
It's good to see that HN continues to find ways to increase pedantry! You know what I meant, intramuscularly.
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hhas01 2015 days ago
“You know what I meant”

No. I am not a mindreader. And “vaccines are injected into the bloodstream” is a standard antivax lie.

Yes there’s a risk in receiving a vaccine, just as there’s a risk in receiving any prophylactic/therapeutic treatment, but severe side-effects are closer to 1-in-100K to 1-in-a-million. Compared to a disease that is currently killing 2-in-100, with significant sequelae likely much higher.

I’m happy to accept that “bloodstream” was a slip of the tongue, but really try not to make those malignant lying bastards’ jobs any easier, when people die because of them.

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nkohari 2014 days ago
If you had actually read what I wrote thoughtfully -- instead of falling over yourself to type a glib reply as fast as you could get it out -- it would have been easy to recognize that I am clearly not anti-vaccine, nor was I suggesting that side effects are common. I said both of those things explicitly.

If your goal is actually to educate others, then educate others. Replying with snark achieves nothing but temporarily boosting your own ego.

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hhas01 2014 days ago
Yes I read your post, and yes it was poorly worded. Take the tip and move on.
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