[heycosmo]

> To assess co-evolution you need a multiple sequence alignment between protein homologs containing correlated mutations.

That makes sense. So in the CASP competition, when teams are given a sequence, do their algorithms do something like the following?

1. Search database for homologs of given sequence 2. Look at MSA and correlated mutations of homologs 3. Look for similar correlated mutations in given sequence

I imagine 1-3 could somehow be embedded in a NN after training on a protein database.

> What do you mean by "proximal"? Close in space, or similar in structure?

I mean close in space.