[zelphirkalt]

I definitely do. It takes some reading the docs and perhaps asking people how to do it, but you can have some environment defining files a folder of any project and use GNU Guix to enter a reproducible environment. I cannot yet do that for all the things, where I would like to do it, because I often miss a package or get an error when trying to import it from other package repositories like PyPI and am not able to solve these without help from the mailing list. People on the mailing list are very helpful though.

Sometimes a good way to do something on the command line is missing, but the stuff that is there has a great CLI interface, in my opinion. One of my favorites is the time machine.