[lnanek2]

The calorie restriction one says: > increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL

Meanwhile SIRT1 has been proven to be life extending via genetically engineering mice to have it: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291425/

So the claim of https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901353/ that this is just shifting damage from one type of damage to another and can't prolong life doesn't seem to hold water.