[tuna-piano]

I'm curious if anyone knows why Pfizer's mRNA vaccine still needs this while Moderna's mRNA vaccine does not?

Has Pfizer just not gone through the proper temperature testing or did they go through that testing and it showed that their vaccine needs to be stored so cold?

[refurb]

The second option. Stability testing is done quite early with any drug candidate and is a requirement for FDA approval. There is zero chance that Pfizer didn't test their vaccine at higher temperatures.

Although Moderna's and Pfzier's vaccines are both mRNA technologies, they aren't identical in either the mRNA itself or the lipid nanoparticle used to deliver the mRNA. That's why they have different stability profiles.

[try-perforate]

Lipid nanoparticle used to envelope and deliver the mRNA. They’re using different makeups which affect the mRNA delivery and stabilization in the vaccine.