[chrismorgan]

Trouble is, that argument falls apart because != is only akin to ≠ if == is actually =. If you use a language with := for assignment and = for comparison (or something similar), sure, making != appear as ≠ might make sense. But if you’re using almost any C-family language, you’ve already broken the mathematical model of what the equals sign means. After that, I side with nicoburns and say that now you’re obscuring what it actually means (in favour of something that’s more or less incorrect in mathematical notation).

[OJFord]

So, use the right ligatures for what you're doing.

Iosevka has several presets, or can be completely configured: https://github.com/be5invis/Iosevka#ligations