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It's "just" 4 GPUs and 64 CPU cores. Nvidia has a flavor of Linux for it, but it's basically just Ubuntu with Nvidia drivers and tools. You can rent a machine pretty similar to this on AWS (P3 instances) for about $12/hour, but it has the last-gen V100 GPUs.

You'd usually run CUDA applications that can take advantage of the GPUs. Deep learning is all the rage these days, and the new A100 GPUs are particularly well-suited. Many HPC applications like computational fluid dynamics simulation take advantage of GPUs nowadays. There are also a number of visualization applications that GPUs excel at.