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Vitamin D is vital for adaptive immune system function too! When a T-cell encounters a foreign pathogen, it extends a vitamin D receptor. A signaling device allowing it to bind to the active form of vitamin D. Only after this can T-cells perform their intended function. [1] Which is likely why healthy levels > 40 ng/mL significantly reduce COVID mortality, there's been > 2 dozen obersvational studies and at least one randomized controlled one. [2] 1. von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C (April 2010). "Vitamin D controls T cell antigen receptor signaling and activation of human T cells". Nature Immunology. 11 (4): 344–49. https://doi.org/10.1038/ni.1851 2. Entrenas Castillo, M., Entrenas Costa, L. M., Vaquero Barrios, J. M., Alcalá Díaz, J. F., López Miranda, J., Bouillon, R., & Quesada Gomez, J. M. (2020). "Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study". The Journal of steroid biochemistry and molecular biology, 203, 105751. https://doi.org/10.1016/j.jsbmb.2020.105751 |