[jb775]

My sister suffered severe TBI from a car accident for 15 years before she eventually passed last year. It was pretty shocking to witness the lack of knowledge in regards to how the human brain works, and more specifically lacking in how to heal/treat an injured brain.

Immediately following the accident, we saw other patients in the same condition as her and tracked their progress for comparison sake. The common theme was that patients either made significant progress (with motor skills, talking, etc) within the first 0-3 weeks, or not really at all. It seemed like once scar-tissue started forming in the brain, critical brain connectivity began to get blocked (not necessarily broken). If we can better understand the underlying mechanism behind the "signal blocking" vs "signal un-blocking" aspect seen using this drug in TBI patients, it would be a huge win for all brain related conditions.

[cblconfederate]

The underlying mechanism is well known: it activates GABA (inhibitory) receptors causing cells to hyperpolarize. We have all kinds of receptor activators/deactivator drugs, the problem is the brain is complex and we don't know where/when/how to use them to achieve desired effects.