[offbynull]

First time I came across this was when I was reading a chapter on genome assembly in a bioinformatics algorithms book. It seemed like such a great solution until it got to the section about practical complications with DNA sequencing: sequencing errors, the fact that that their are 2 strings being assembled (double stranded DNA), repeats in the genome, etc..

[anderspitman]

You've basically summarized the field.