FWIW for most of these sorts of things you can scrub it via passing the text through an NFKC or NFKD transform. I'd hope that a screen reader can be updated to handle this case.
These are Unicode characters intended for use in mathematical formulas, not text, so they break all sorts of things. It might make some sense to use them in mathematical Python code (where they do seem to work), but they're hard to type.
๐จ๐ป๐ถ๐ฐ๐ผ๐ฑ๐ฒ ๐ต๐ฎ๐ ๐ฐ๐ต๐ฎ๐ฟ๐ฎ๐ฐ๐๐ฒ๐ฟ๐ ๐๐ต๐ฎ๐ ๐น๐ผ๐ผ๐ธ ๐๐ถ๐บ๐ถ๐น๐ฎ๐ฟ ๐๐ผ ๐ณ๐ผ๐ฟ๐บ๐ฎ๐๐๐ฒ๐ฑ ๐๐ฒ๐ ๐.
๐๐๐๐๐๐๐ โ๐๐ ๐โ๐๐๐๐๐ก๐๐๐ ๐กโ๐๐ก ๐๐๐๐ ๐ ๐๐๐๐๐๐ ๐ก๐ ๐๐๐๐๐๐ก๐ก๐๐ ๐ก๐๐ฅ๐ก.
๐๐ฏ๐ช๐ค๐ฐ๐ฅ๐ฆ ๐ฉ๐ข๐ด ๐ค๐ฉ๐ข๐ณ๐ข๐ค๐ต๐ฆ๐ณ๐ด ๐ต๐ฉ๐ข๐ต ๐ญ๐ฐ๐ฐ๐ฌ ๐ด๐ช๐ฎ๐ช๐ญ๐ข๐ณ ๐ต๐ฐ ๐ง๐ฐ๐ณ๐ฎ๐ข๐ต๐ต๐ฆ๐ฅ ๐ต๐ฆ๐น๐ต.
๐ผ๐๐๐๐๐ ๐ ๐๐๐ ๐๐๐๐๐๐๐๐๐๐ ๐๐๐๐ ๐๐๐๐ ๐๐๐๐๐๐๐ ๐๐ ๐๐๐๐๐๐๐๐๐ ๐๐๐๐.
๐๐ฃ๐๐๐ค๐๐ ๐๐๐จ ๐๐๐๐ง๐๐๐ฉ๐๐ง๐จ ๐ฉ๐๐๐ฉ ๐ก๐ค๐ค๐ ๐จ๐๐ข๐๐ก๐๐ง ๐ฉ๐ค ๐๐ค๐ง๐ข๐๐ฉ๐ฉ๐๐ ๐ฉ๐๐ญ๐ฉ.
(Don't do this: it's _terrible_ for accessibility, as screen readers can't parse these as regular text)