[jaypeg25]

It's already clear that the vaccine, when it gets released, won't be a one time thing and we'll need more in the future to counter the mutations. Unfortunately, just in anecdotally talking to friends about it, it doesn't seem that this is widely known. It will be interesting to see how things play out as more people start to realize this. I suspect a lot of anti-vaxxers will be even more emboldened by it.

[ComputerGuru]

I don’t think anything is “clear” - there are even indications that people exposed to the original SARS virus have their immune systems primed to more quickly respond to SARS-CoV-2.

[peter422]

I do not think mutations are the main problem, just the fading of immune system memory.

But it does seem very likely the vaccine will not be a one time shot and you’re good forever.