[donbrae]

In my admittedly limited testing I cannot fault the Figma web app in terms of responsiveness. Maybe it struggles with larger projects?

I think the web generally has these kind of use cases covered, although it would be nice to have the other things you mention (file system/iCloud integration, better accessibility [based on my understanding of Canvas' limitations in this area] etc.).

On the other hand, applications like Logic or Final Cut would be pretty much impossible to build in the browser.