[formerly_proven]

I see a lot of tracing and sampling profilers for Python, but are there any profilers for manual instrumentation (goes by a bunch of names, frame profiling, performance telemetry, APM etc.)?

[gnufx]

As an example, https://github.com/score-p/scorep_binding_python#user-region... is the support in the HPC system https://score-p.org (though it focuses on parallel programs). http://apps.fz-juelich.de/scalasca/releases/cube/4.5/docs/gu... is the associated profile analysis tool.