Yes, I do. His stuff is often poorly researched and presented for maximum entertainment value rather than for accuracy. I may be pretty close to him politically but his stuff is mostly just entertainment.
Last Week Tonight and a similar German show heute Show are the worst, because the make fun of people from an assumed moral high ground, which they do not have. They really want to show their viewers; "Ha, look how stupid other people are. It's alright to laugh about them, because they are so dumb. Good thing we the good ones!". It is absolutely despicable.
South Park never does this. They just make fun of people or current trends in society, without evaluating them morally. They are more drastic, but never claim moral superiority.
Kinda? South Park is more obscene, but I’ve seen quite a few Last Week Tonight clips where the takeaway is clearly meant to be “haha, those people are such dummies!” I really do get it, and I personally enjoy both shows, but the genre of political humor tends to inevitably involve cheap shots at political opponents.
They aren't even remotely the same type of show! I don't know how you could possibly try to compare them. You wouldn't try to compare the Super Bowl against Downton Abbey, would you?