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by xiphias2 2076 days ago
According to the Hallmarks of Aging paper DNA inside the nucleus is relatively stable, and the epigenetic material (i.e. DNA methylation) is a much better predictor of aging, as the proteins can't be transcribed if the DNA is methylated at those parts.

That's why is such a big thing that reversing methylation already happened in humans, as it means that the human body already knows how to regenerate itself (just like other animals), we just don't yet know how to turn on the regeneration pathways safely.

1 comments

Relatively stable is not enough, as we can see from how common cancer is.