Only on Ubuntu, in which the first click must be "0". On Windows it could for example be "2" and then you have to guess which of the adjacent 8 cells are the 2 mines...
That's not what's being discussed here; the above comments talk about whether it's guaranteed that the first click is not a mine, not that it's not adjacent to a mine. As far as I'm aware, just about every version guarantees that the first click is not a mine, but many (such as the Windows original) allow the first click to be adjacent to a mine.
There are some variants without luck. For example there was one which guaranteed that you never get a mine when you have to guess, but always get one when you guess in a situation where you can still open another field safely.