[rgoulter]

Vim is a very keyboard-oriented program.

Dvorak with vim isn't that bad. HJKL is in a row on QWERTY, but Dvorak at least has JK together, and H to the left of L.

CUA keybindings like Ctrl X, Ctrl C, Ctrl P can be a pain with Dvorak. (I also don't think shortcuts like Ctrl+Insert, Shift+Insert are widely supported across OSs, nor USB HID's copy and paste keys).

Other than that, it's just about remembering the shortcut by the letters, not by the position of the keys.