I dunno, it was a pretty enlightening experience, learning how to struggle, learning how to be humble about sucking at something that for me till then was super basic (as an adult, so I could really savor the feeling -- I had learned to touch-type at age six). If you don't forget qwerty, it's not an annoyance to use someone else's keyboard. And having someone else be annoyed when they use my keyboard is a feature =).
The only time it was mildly annoying was when I started dating someone and asked to use her laptop, and I suddenly found I couldn't type. It turned out that she had ALSO learned dvorak in college. When I realized what was going on it was all good.
To make your setup really unusable, use a 60% layout with blank key caps and VIM. :-)
I use this setup + qwerty in an azerty region, needless to say my setup does not get used a lot for pair programming. I actually did have a spare keyboard in my desk drawer for a long time just in case someone really wanted to use my machine before I went full-time WFH.
The only time it was mildly annoying was when I started dating someone and asked to use her laptop, and I suddenly found I couldn't type. It turned out that she had ALSO learned dvorak in college. When I realized what was going on it was all good.