[jszymborski]

tl;dr very much so, yes

Cells are very subdivided, and the ease with which macromolecules traverse these spaces varies greatly. There are organelles and the nucleus that require only let certain proteins in and and out and at certain rates.

There are also kinds of tar-pits that keep certain proteins around for longer.

Stress granules and vesicles also gobble-up macromolecules into these fun party bags that burst in certain contexts.

Sometimes you even have complexes of macromolecules like ribosomes whose entire job is to intercept other macromolecules so that they might interact (there is a subtle difference between enzymes/catalysis here if I understand correctly)