WSL2 is by far superior to running Windows in a VM, mostly because it's not "just" Linux in VM.
And anyway, just the way it lets me manage multiple instances of Linux is far superior to anything I experienced on Mac or Linux itself. By the current standards, Wine is just _painful_ to use. Meanwhile Windows window management and the terminal app have made great strides in last couple years.
WSL2 still can't be superior to Linux proper even if it's not just Linux in VM (which it mostly is, just with specific integration with Windows). There is still hypervisor involved no matter how you slice it.
So if you do need to run something that's Windows only but can work in Wine, I'd totally recommend running using Wine ditch Windows for good. For me it's a benefit, not a hindrance.
And you can run multiple VMs on Linux too if you need actual Windows still (KVM, virt-manager and etc. are quite handy).
And anyway, just the way it lets me manage multiple instances of Linux is far superior to anything I experienced on Mac or Linux itself. By the current standards, Wine is just _painful_ to use. Meanwhile Windows window management and the terminal app have made great strides in last couple years.