[JPLeRouzic]

A few comments:

* We already have good PK/PD models, PBTK, human physiology models based on differential equations, and toxicity prediction servers. If it was integrated in a smart and easy to use software suite, it would do a lot to reduce the cost of clinical trials. We could even incrementally improve this with toxicicity prediction servers that would be aware of physiology [0].

* You can certainly try to make a good model of mice physiology, as dr Guyton did for humans 50 years ago. But how can you answer a medical question with this model? Let say you want to create a drug for type II diabetes. How can any kind of biology model help you in this task? You would need to run some kind of genetic algorithm on this model, so it would be extremely slow and costly.

* Instead of scaling with mice, you can use organoids, it will be much more realistic, and you will not have the effect that drugs work on mice model but not on humans. Which brings this question: To design organoids you need to have a very good understanding of their biology, but this is what you want to discover!

[0] https://pubmed.ncbi.nlm.nih.gov/28522333/