[OzzyB]

You have thrown out quite the list there (Blockchain/AWS/etc), which I guess is more of an indictment of where we're at an industry today regarding tools, than any criticism on your part.

If you are truly starting out fresh/green, I would ignore all the buzzwords, and simply focus on how to make a solid, good 'ol fashioned web app.

For this I would suggest learning/reading up on the Django Framework. The docs are excellent, kind to newcomers, and will walk you through all the main architectural considerations and components needed to make a robust fully featured app - databases/orm, controllers, templating etc.etc.

Once you've built a (few) webapps like this then you can worry about spending time refactoring parts of it with the new hotness. They will reveal themselves to you once you get some experience and grow your app/business, and you'll have the knowledge to make better decisions on whether or not they're worth it.

For now just stick with a framework that will guide you; ofc it doesn't have to be Django, there is Ruby on Rails and many others, and remember even the first iteration of Instagram was a Django app!