[memossy]

I will try to get back to this thread with some resources but I would recommend as you are in the UK to look into clemastine/tavegil which you can get without prescription (noted in the article as about to be trialled with metformin) due to its action on P2X7 receptors/Schwann cells.

The ReBUILD doses were rather high though (10 tabs a day!). 1 tab would probably do it over a few months.

[medical_alt]

That's interesting. Just take care with that. There's some epidemiological evidence that anticholenergics like clemastine may possibly contribute to dementia:

https://www.health.harvard.edu/blog/common-anticholinergic-d...

The data suggest correlation, not necessarily causation, but at the least I'd carefully investigate the risks before taking any anticholergic in such high doses. I do understand (with my own chronic health issues) that even with the risk of dementia later on, it may still be a possibility, depending on the severity of current symptoms.

[GordonS]

> look into clemastine/tavegil

Thanks, I've never even heard of clemastine, and it's rare to find anything notable that doesn't require a prescription in the UK! I already take another gen 1 antihistamine at night (they are very sedating for me), so I guess could swap it for clemastine.

Now all I need to do is convince someone to give me a prescription for metformin...