[nnmg]

> Prineas in 2001 showed that MS progression may occur in the absence of immune cells and inflammation

MS researcher here. MS as an autoimmune attack is largely settled in mainstream neuroscience. The paper you cited does not show what you said it does. From the paper: > restricted largely to short segments of disrupted myelin located within linear aggregates of microglial cells

The paper is interesting because it shows that demyelination is happening in lesions that we thought were inactive, but actually do contain microglia and macrophages (immune cells) eating myelin (i.e. an autoimmune --immune system attacking self-- attack). The paper is paywalled but I but you can read it on sci-hub (https://sci-hub.scihubtw.tw/10.1002/ana.1255) Although just reading the abstract says the opposite of what you are claiming, the entire thing is about microglia and macrophages contributing to lesions that the researchers thought were inactive.

[doctor_eval]

OK. I might be quoting the wrong paper, and I’m not a researcher, but I remember clearly that he found a case (14yo girl IIRC) who died during an attack, and there was no immune activity at the site of at least one of the lesions.

If I’m wrong about this then I will accept it, I don’t have an axe to grind.