[npwr]

On the contrary that would make the possibility that the great filter is the appearance of a cell very unlikely.

That leaves these possible obvious filters: single cell to multicellular life or planetary resources exhaustion.

[_kst_]

The development of multicellular life is unlikely to be the great filter. According to Wikipedia, "Multicellularity has evolved independently at least 25 times in eukaryotes". https://en.wikipedia.org/wiki/Multicellular_organism#Occurre...

Evolution of eukaryotes from prokaryotes is a more plausible bottleneck. (Disclaimer: I am not an expert on any of this.)