[ISL]

A note of sympathy here, as people in sibling posts seem to be seeing this choice in a negative light regarding the resign-er's self-worth or competence. Leaving can be a powerful expression of "I have tried my best, hung on as long as I can. I love this place, and I love what we do, but I cannot stay. Something is broken."

It can be a hard choice, but one that sets an example for your colleagues: there are some situations which a person cannot abide ad infinitum.

If the situation pushed you so far as to resign, then you made an important choice.