[tleb_]

The idea is that on none random data, you are able to use a heuristic that would create variable-sized chunks that fit the data. The simplest way seems to detect padding zeros and start a new block on the first following none zero byte. There probably are other ways, knowing the data type should help.

[hinkley]

That seems fairly unlikely. Not a lot of big files have zero padding, and if they did them compress them. It will reduce your transfers more than and range substitutions ever will.