[chuckmcknight]

For native apps, I've had success using:

wxWidgets (C++) / wxPython (Python) Qt (C++) / PyQT (Python)

Mike Driscoll has a recent ebook on wxPython that is a good jumpstart if you are familiar with Python. There are a host of other resources for Qt/PyQt available via Google.

You can, of course, use any of the NodeJS frameworks as well. In the absence of any clear requirements, any of these will work.