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by cmendel 2120 days ago
Alpha-ketoglutarate for those who don't want to read the article.

Here's the Wikipedia page: https://en.wikipedia.org/wiki/Alpha-Ketoglutaric_acid I don't expect it to be terribly helpful though, it's a bit dense to the layperson.

1 comments

It's a metabolic intermediate of the citric acid cycle - the cycle is needed to reduce electron carriers (NAD+/FAD) which are then used to drive the electron transport chain for making ATP. In simplest terms: it's an important part of aerobic respiration.

That being said, it can be synthesized de novo very easily so long as your cells have enough glucose/fatty acids and enzymes are functioning properly. It's even formed directly by deamination of glutamate. I'm not sure these results would be very transferrable to humans.