One of my favorites is (spoiler alert) Incandescence, which presents the utterly novel concept of an alien civilization whose faculties, environment, and thought processes are totally un-human. The characters in this story very gradually discover the principles of relativity from scratch.
For me reading this book, the process of understanding what it is that they are understanding ends up conveying very little useful information of how humans understand physics -- a bizarre and thought-provoking experience.
Greg Egan books expand the brain in weird ways. They can be a bit of a chore till you hit a point where the narrative has grabbed you, but once that happens, it an amazing ride.
Reading his books make me feel stupid and clever at the same time.
Pun unintended?