[zx2c4]

Actually, WireGuard has first class support now on a large number of distros, without the need for any additional compilation: Ubuntu 16.04, 18.04, 20.04, Fedora, Debian, OpenSUSE, Arch, Mandriva, Alpine, Nix, Void, OpenWRT, and others. Check out www.wireguard.com/install/ for the whole list.

[WGH_]

AFAIK most of these are DKMS, so compilation (although automated and supported by distro) is still necessary.

[lima]

At least it will eventually propagate to all distros now that it's in the stable kernel!

Fedora and other distros with recent kernels already have it.

[iso947]

Even windows