In the UK the warning was BMI of over 35 needs to be careful, >40 needs to isolate. That would be a hell of a lot of americans. Plus the diabetics, heart issues, elderly etc.
I don't know what the ripple effect is. Might be very close (after all, less than half the americans do work).
And you don't need that many people to isolate for the house of cards to crumble. Plenty shops need to close because 30% fewer customers isn't enough to sustain them