[missedthecue]

Unless the vaccine kills a lot of people, I don't see more resistance to future vaccines being likely (that is, more resistance than there is at present). If it fails and gives them coronavirus, it's not a big deal. If it fails and does nothing, it is also not a big deal. It's not like the same risk of giving them polio or smallpox or something.

[tuatoru]

If it fails and sensitizes people to the virus, so that they have more severe reactions to it, it could be a very big deal.

If vaccination causes people to relax other hygiene practices due to a false belief that the vaccine protects them, then that will make the next wave worse.