[otterlicious]

If you want NumPy support in particular you basically have to use CPython.

The only other implementation that really supports it is PyPy which is not in any sense more lightweight.

[matt_trentini]

Although much smaller in scope than NumPy, MicroPython (and CircuitPython) now have the ulab library which provides similar fast array manipulations:

https://github.com/v923z/micropython-ulab