[sungam]

Caloric restriction is the only non-genetic intervention proven to increase maximal lifespan in mammals. However it may well be that the magnitude of this effect in humans is considerably smaller than in lower mammals because the mechanisms that repair the damage that accumulates as a consequence of normal metabolism are already more optimal. I think the really interesting area is caloric restriction mimetics. These are alluded to in the article and are a class of small molecule compounds that aim to induce the life-extending effect of CR without the need for reducing calories. GSK recently made a 0.75 billion dollar investment in Sirtris pharmaceuticals http://www.sirtrispharma.com/pipeline-candidates.html who are developing a reversatrol derivative so this is far from science fiction.