[aldanor]

For algorithmic/numerical code, especially if you have to deal with numpy-related data, Numba has a much easier barrier for entry, plus you remain with cpython while speeding up computation-intensive code by a few orders of magnitude.

[laurencerowe]

Looks like numba has cffi support now so it would be an option. If I can dig out the code (it was about 5 years ago) I'll probably try adapting it to numba to benchmark it against pypy.