I think someone attempting to get an Uber pickup (or getting dropped off by an Uber) in the middle of CHOP/CHAZ might have had some problems. Particularly at night.
Or any "drop me off within the ongoing protest" ride, really.
Problems? Sure. It's going to be hell to try and get in and out of the area, since you'll have to either go at about two miles an hour while people move out of the way (while regularly stopping and waiting for unorganized crowds), or just go around the long way.
If you're going to include individual incidents, you should include the CHAZ/CHOP shooting, and the various "people beat up the car as it drives through" occurrences too. Sure, those cars may have done something to offend/anger/threaten the protesters, but...
The point is some places in some cities at some times carry high risk to whoever drives there. I consider it immoral for the company to force an employee (or contractor) to go to such high-risk place, and for that person I think makes complete sense to refuse going to such place and risk their assets (e.g. car) and their health for a relatively small payment.
Portland, Seattle and Chicago are examples of the cities which had recently well-documented examples of some areas being dangerous and carrying risk of violent encounters.