[pete762]

> I am disabled with Anxiety and Mood Disorder and chronic fatigue/depression. Typical "Bipolar" presentation. It runs in my family on my mothers side.

That sounds awfully familiar. Would you be so kind to provide any starting point to begin research into this, including the supplement stuff you mentioned afterwards?

[podgaj]

I would start by getting your full genome run, or at least get it from Ancestry. Then learn how to look at the low frequency SNPs. I am lucky as I live near UNC Chapel Hill that has several departments looking into this stuff.

The supplements came after I saw my genetics and from past anecdotal experiments. But maybe start by understanding the electron Transport chain. When I saw all the oxidative stress created there I began looking at the several pathways for the flow of O2- and H2O2. To me, mood disorders have their root in this flow being unobstructed.

Riboflavin ended up being big for me for several reasons.

Keep in mind, mood disorders are polygenic, may causes, so for you it might be something with Monoamines or what ever.

I wish doctors would get serious about testing for these deficiencies in people wit mood disorders...

[jackspawn]

Can you tell me which SNPs were relevant for you? Or are generally relevant for depression?

I checked https://www.snpedia.com/index.php/Depression but maybe you know better which SNPs are most important?

I got my genome and checked it using promethease, but 'sadly' I didnt get any major 'depression' hit; only minor SNPs which were correlated with 1.5x more probability to get depression

And I got no advice on which diet could help me :)