[Mouse47]

That's a good point! The only reason I'm comfortable self-experimenting on this one is that 1) there's already evidence that frequent blood donors outlive non-donors (obviously that's an observational study, but still) and 2) there's actually already a clinical use for plasma replacement therapy in Alzheimer's that's roughly identical to the one done in the study.

In addition - they theorize that it's a buildup of bad elements in the blood that causes some runaway process that contributes to aging, so it might follow that less extreme interventions (~15% removal of blood plasma, like plasma donation, which takes around 800 ml out of the ~5500 ml of plasma in your body) done more frequently might provide the same effect.

You're right though - totally unproven.