Nope. The three laws are unequivocal. The universe can only increase or maintain entropy through physical processes. It can never return to a lower-entropy state. The laws say nothing about the topography of the universe and it wouldn’t matter anyway.
When you dig into it more you realize the second law of thermodynamics is more of a statistical statement and doesn't have the same status as say the laws of quantum mechanics or relativity.
It's possible to create hypothetical situations where all of the must fundamental laws are being followed but the second law of thermodynamics is violated (for example if there are many more 'ordered' states than 'disordered' ones). And there is some vanishingly small chance that it will be violated in our universe for a macroscopically observable length of time.
In practice you won't go wrong by treating it as absolute.
Actually, there is debate about the conservation of energy over cosmological length scales.
e.g. if new voxels of spacetime are created during, and they contain zero-point energy... may account for photons losing energy as they red shift over large distances.
Yes, at large scales space expansion can sort of make it so energy is not conserved: http://www.preposterousuniverse.com/blog/2010/02/22/energy-i... Depending on how you look at it, anyhow. One way or another you end up with some sort of unintuitive concept being introduced.