[Mouse47]

Exactly. In fact, the authors note that the effect on their own defined markers of aging was more significant when using saline + albumin than when using young blood.

>In our paper, we looked at the hippocampal neurogenesis, which is the formation of new neurons in the area of the brain that is responsible for learning and memory. We saw an eightfold increase in all the animals after neutral blood exchange, which is much higher than anything else that was observed either by heterochronic parabiosis or reported by young blood infusion. In old mice transfused with 50% young blood, we did not see an improvement in neurogenesis, which, again, puts a question mark on potency of young blood in old mammals. Does young blood by itself work as a medicine or not? If you dilute old blood by 50%, in neutral age blood exchange – with albumin-supplemented saline, there is quickly better neurogenesis.